Just one day after 23 Houston companies were honored on Fortune's list of the top 500 grossing companies in America, the city is in grave danger of toppling off its pedestal as one of the nation's most flourishing metropolises.

On Friday, clear signs of lethargy had descended upon the city's workforce. Record numbers had called in "sick" and offices city wide were quiet, clammy and nauseous. Something smelled different — and not in a good way.

Cinco de Drinko had obviously taken its toll, and the extent of its aftermath has yet to be determined.

A sampling of the Twitter messages some Houstonians still managed to get out the day after Cinco de Mayo include:

"Ugghhh. May 6th. #hungover."

"Why yes Rich Hardesty, I am a little hungover. I did not however take a leak in the drain."

"Last night was not OK."

"I am not OK."

"I woke up with no phone, no wallet, no shirt, no pants and no shoes. Wallet cannot be found. Phone was in car. Pants, shirt and shoes piled on hood of car."

And "Pedialyte: The breakfast of champions."

The depth of this dent to Houston's earnings is unforeseen. But in lighter news, El Pueblito earned its cost for the next five years.