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    the methodist method

    Houston hospital first in nation to deliver crucial new coronavirus treatment

    Steven Devadanam
    Mar 31, 2020 | 9:25 am
    Coronavirus testing COVID-19 testing lab doctor test
    Houston Methodist is the first academic hospital in the U.S. to begin a critical new treatment option against COVID-19.
    Photo by Getty Images

    A major Houston hospital is spearheading a crucial treatment in the ongoing battle against COVID-19. Houston Methodist is the first academic medical center in the nation to be approved by the FDA to transfuse donated plasma from a recovered COVID-19 patient into a critically ill patient.

    The experimental treatment was fast-tracked as the death toll in the coronavirus pandemic soared to more than 2,000 people across the United States and more than 100,000 Americans sick from the virus, according to a statement.

    The concept of the treatment centers around the idea that plasma from someone who has recovered from COVID-19 contains antibodies made by the immune system and used to kill the virus. Transfusing antibody-rich plasma into a COVID-19 patient who is still fighting the virus may transfer the power of the antibodies into a healing, possibly life-saving therapy, per the hospital.

    Donating plasma is similar to donating blood and takes about an hour, according to Methodist. Plasma donors are hooked up to a small device that removes plasma while simultaneously returning red blood cells to their bodies. Unlike regular blood donation in which donors have to wait for red blood cells to replenish between donations, plasma can be donated more frequently, as often as twice a week.

    Known as convalescent serum therapy, the concept dates back more than a century, when similar treatments were used during the Spanish flu pandemic of 1918, a diphtheria outbreak in the 1920s, a flesh-eating bacteria epidemic in the 1930s, and during other outbreaks of infectious diseases.

    Most recently, a description of the treatment of five patients in China was published this week in the Journal of the American Medical Association, suggesting that the treatment was beneficial.

    According to Methodist, scientists there recruited blood plasma donors from among approximately 250 patients who have tested positive for the COVID-19 virus at Houston Methodist hospitals. Willing donors were immediately identified; each gave a quart of blood plasma in a procedure much like donating whole blood.

    The first recovered COVID-19 patient to donate plasma was an individual from the Houston metropolitan area who has been in good health for more than two weeks, according to the hospital. The plasma was then transfused into a COVID-19 patient at Houston Methodist.

    Houston Methodist’s convalescent serum therapy treatment is classified as an “emergency investigational new drug protocol” that requires FDA approval for each patient infused with donated convalescent serum, according to the hospital. Houston Methodist physician scientists will continue to seek additional FDA approval for follow-up studies, as time is of the essence.

    “Convalescent serum therapy could be a vital treatment route, because unfortunately there is relatively little to offer many patients except supportive care, and the ongoing clinical trials are going to take a while,” said Dr. Eric Salazar, principal investigator and a physician scientist in the Department of Pathology and Genomic Medicine at the Houston Methodist Hospital and Research Institute, in a statement. “We don’t have that much time.”

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    Business news

    Houston company ranks No. 13 worldwide on new Forbes Global 2000 list

    John Egan
    Jun 17, 2025 | 2:00 pm
    Houston skyline
    Coalition for the Homeless of Houston Facebook
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    More than 60 Texas-based companies appear on Forbes’ 2025 list of the world’s 2,000 biggest publicly traded companies, and nearly half come from Houston.

    Among Texas companies whose stock is publicly traded, Spring-based ExxonMobil is the highest-ranked at No. 13 globally.

    Rounding out Texas’ top five are Houston-based Chevron (No. 30 globally), Dallas-based AT&T (No. 35 globally), Austin-based Oracle (No. 66 globally), and Austin-based Tesla (No. 69 globally).

    Ranking first in the world is New York City-based J.P. Morgan Chase.

    Forbes compiled this year’s Global 2000 list using data from FactSet Research to analyze the biggest public companies based on four metrics: sales, profit, assets, and market value.

    “The annual Forbes Global 2000 list features the companies shaping today’s global markets and moving them worldwide,” said Hank Tucker, a staff writer at Forbes. “This year’s list showcases how despite a complex geopolitical landscape, globalization has continued to fuel decades of economic growth, with the world’s largest companies more than tripling in size across multiple measures in the past 20 years.”

    The U.S. topped the list with 612 companies, followed by China with 317 and Japan with 180.

    Here are the rest of the Texas-based companies in the Forbes 2000, grouped by the location of their headquarters and followed by their global ranking.

    Houston area

    • ConocoPhillips (No. 105)
    • Phillips 66 (No. 276)
    • SLB (No. 296)
    • EOG Resources (No. 297)
    • Occidental Petroleum (No. 302)
    • Waste Management (No. 351)
    • Kinder Morgan (No. 370)
    • Hewlett Packard Enterprise (No. 379)
    • Baker Hughes (No. 403)
    • Cheniere Energy (No. 415)
    • Corebridge Financial (No. 424)
    • Sysco (No. 448)
    • Halliburton (No. 641)
    • Targa Resources (No. 651)
    • NRG Energy (No. 667)
    • Quanta Services (No. 722)
    • CenterPoint Energy (No. 783)
    • Coterra Energy (No. 1,138)
    • Crown Castle International (No. 1,146)
    • Westlake Corp. (No. 1,199)
    • APA Corp. (No. 1,467)
    • Comfort Systems USA (No. 1,629)
    • Group 1 Automotive (No. 1,653)
    • Talen Energy (No. 1,854)
    • Prosperity Bancshares (No. 1,855)
    • NOV (No. 1,980)

    Austin area

    • Dell Technologies (No. 183)
    • Flex (No. 887)
    • Digital Realty Trust (No. 1,063)
    • CrowdStrike (No. 1,490)

    Dallas-Fort Worth

    • Caterpillar (No. 118)
    • Charles Schwab (No. 124)
    • McKesson (No. 195)
    • D.R. Horton (No. 365)
    • Texas Instruments (No. 374)
    • Vistra Energy (No. 437)
    • CBRE (No. 582)
    • Kimberly-Clark (No. 639)
    • Tenet Healthcare (No. 691)
    • American Airlines (No. 834)
    • Southwest Airlines (No. 844)
    • Atmos Energy (No. 1,025)
    • Builders FirstSource (No. 1,039)
    • Copart (No. 1,062)
    • Fluor (No. 1,153)
    • Jacobs Solutions (1,232)
    • Globe Life (1,285)
    • AECOM (No. 1,371)
    • Lennox International (No. 1,486)
    • HF Sinclair (No. 1,532)
    • Invitation Homes (No. 1,603)
    • Celanese (No. 1,845)
    • Tyler Technologies (No. 1,942)

    San Antonio

    • Valero Energy (No. 397)
    • Cullen/Frost Bankers (No. 1,560)

    Midland

    • Diamondback Energy (No. 471)
    • Permian Resources (No. 1,762)
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