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    Kicking Cancer's Butt

    A breast cancer breakthrough at M.D. Anderson? New vaccine helps prevent relapse

    Whitney Radley
    May 16, 2012 | 6:25 pm

    Good news for breast cancer patients: A post-treatment vaccine currently in its second phase of clinical trial at Houston's M.D. Anderson Cancer Center has proven to prevent disease recurrence by a significant margin.

    Patients on the vaccine were 43 percent less likely to have a cancer recurrence. The secret weapon is AE37, a peptide vaccine that helps the body to raise immunity against HER2, the growth-promoting oncoprotein present in nearly 80 percent of breast cancer tumors.

    Cassady flies to Houston once a month, receives two AE37 shots in her leg, then stays for 48 hours to check up with the doctors.

    Dr. Elizabeth Mittendorf, assistant professor in the Department of Surgical Oncology at M.D. Anderson and principal investigator for the nation-wide study, told CultureMap that preliminary results suggest the AE37 vaccine may benefit patients with low levels of HER2 expression as well, when used in conjunction with other adjuvant treatments.

    "The vaccination has been met with enthusiasm by the researchers and the patients," Mittendorf tells CultureMap.

    After completing treatment from an oncologist, the patient begins receiving the primary vaccination series — monthly inoculations for six months. To increase efficacy, booster shots are given to the patient every six months over the next three years (the window of time that patients see the greatest risk of recurrence). Side effects are typically minimal.

    Such is the case with Ann Cassady, an M.D. Anderson patient from Knoxville, Tenn., who underwent a double mastectomy, one lymphadenectomy, six months of chemotherapy and a month and a half of radiation before signing up for the study in February.

    "I just had a treatment this morning," Cassady says. "I've experienced no side effects whatsoever."

    Cassady flies to Houston once a month, receives two AE37 shots in her leg, then stays for 48 hours to check up with the doctors. Cassady said the after-effects of the inoculation are comparable to a mosquito bite itch.

    The study finds that, at a 22-month follow up, former breast cancer patients had a 10.3 percent recurrence rate (compared to 18 percent in a control group). Those conclusions will be presented on June 4 at the annual meeting of the American Society of Clinical Oncology.

    A third phase of the study will follow after Antigen Express, the company that licenses the AE37 technology, applies for a special protocol assessment from the FDA.

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    income analysis

    Texas families need to make this much money for one parent to stay home

    Amber Heckler
    Dec 8, 2025 | 9:30 am
    Stay at home parents, SmartAsset, income analysis
    Photo by CDC on Unsplash
    With costs to raise a child soaring over $20,000 a year in Texas, some households might decide to have one parent work while the other stays at home to raise their child.

    As the cost of raising a child balloons in major cities like Houston, many families are weighing the choice between paying for child care or having one parent stay home full-time.

    A recent analysis from SmartAsset determined the minimum income one parent needs to earn to support their partner staying at home to raise one child in all 50 states. In Texas — not just Houston — that amount is just under $75,000.

    The study used the MIT Living Wage Calculator to compare the annual living wages needed for a household with two working adults and one child, and a household with one working adult, a stay-at-home parent, and one child. The study also calculated how much it would cost to raise a child with two working parents based on factors such as "food, housing, childcare, healthcare, transportation, incremental income taxes and other necessities."

    A Texas household with one working parent would need to earn $74,734 a year to support a stay-at-home partner and a child, the report found. If two parents worked in the household, necessitating some additional costs like childcare and transportation, it would require an additional $10,504 in annual income to raise their child.

    SmartAsset said the cost to raise a child in Texas in a two-working-parent household adds up to $23,587. Raising a child in Houston, however, is somewhat more affordable. A separate SmartAsset study from June 2025 determined it costs $21,868 to raise a child in the Houston-Pasadena-The Woodlands metro.

    In the report's ranking of states with the highest minimum income needed to support a family with one working adult, a stay-at-home parent, and one child, Texas ranked 32nd on the list.

    In other states like Massachusetts, where raising a child can cost more than $40,000 a year, the report acknowledges ways families are working to reduce any financial burdens.

    "This often includes considerations around who’s going to work in the household, and whether young children will require paid daycare services while parents are occupied," the report said. "With tradeoffs abound, many parents might seek to understand the minimum income needed to keep the family afloat while allowing the other parent to stay home to raise a young child."

    The top 10 states with the lowest minimum income threshold to support a three-person family on one income are:

    • West Virginia – $68,099
    • Arkansas – $68,141
    • Mississippi – $70,242
    • Kentucky – $70,408
    • North Dakota – $70,949
    • Oklahoma – $71,718
    • Ohio – $72,114
    • South Dakota – $72,218
    • Alabama – $72,238
    • Nebraska – $72,966
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