Manos sucias follows Jacobo (Jarlin Javier Martinez) and Delio (Cristian James Abvincula), estranged brothers who reunite on a lucrative drug run. Jacobo seems hardened beyond his years, in contrast to the cheerful and optimistic Delio. Both have reasons for taking this extreme risk: Jacobo wants to move to Bogotá while Delio, from a fishing village with few opportunities, dreams of making it big as a rapper.

Over the course of this tense action-drama, the brothers quarrel, reminisce, face deadly scenarios and recover the fraternal connection they once knew. Produced by Spike Lee, this Colombia-set debut feature from director Josef Wladyka tells a heartfelt and harrowing story of smugglers.