Agnes is a lonely waitress with a fondness for isolation. Peter is a Gulf War drifter. As an unexpected love affair develops in a seedy Oklahoma City motel room, mysterious bugs begin to take over their space. Are they simple pests or could they be the result of military experiments?

The couple's fears soon escalate to paranoia, conspiracy theories, and twisted psychological motives that disrupt any attempt at normalcy. A Tracy Letts cult classic, Bug explores the darkness in the void.