Nic Nicosia is the first major publication of the artist's work and covers his entire oeuvre through 2011. Accompanying the catalog is an overview of Nicosia's career by Menil curator Michelle White, an interview with the artist by Sue Graze and an original short story by Philipp Meyer.

The catalog presents images from all of Nicosia's major photographic series, including Domestic Dramas, Near (modern) Disasters, The Cast, Life as We Know It, Real Pictures, Love + Lust, Acts, Sex Acts, Untitled Landscapes, 365 SaFe Days, Untitled (drawing), Space Time Light, I See Light and in the absence of others, as well as stills from the videos Middletown, Moving Picture, Middletown Morning, Cerchi E Quadratti, On Acting America and 9 1/2 Hours to SaFe.